Initial Approval Criteria
A.  
Multiple Myeloma and 
Mantle Cell Lymphoma (must meet all):
1. Diagnosis of one of 
the following (a or b):
a.   
Multiple Myeloma
b.   
Mantle Cell Lymphoma 
(B-cell lymphoma subtype);
2. 
Prescribed by or in consultation with an 
oncologist or hematologist;
3. Age > 18 years;
4. Request meets the following:
           
a. Dose 
does not exceed 1.3mg/m2;
5. 
Dose is supported by practice guidelines or 
peer-reviewed literature for the relevant off-label use (prescriber 
must submit supporting evidence).
 
Initial Approval 
Duration: 6 months.
 
B.  
NCCN Recommended Uses 
(off-label) (must meet all):
 
1.   
Diagnosis of one of the 
following (a-h):
a.   
AIDS-related Kaposi 
sarcoma (advanced cutaneous, oral, visceral, or nodal disease) – after 2 or more 
prior lines of systemic therapy
b.   
Multicentric Castleman’s 
disease (B-cell lymphoma subtype) – as subsequent therapy
c.   
Systemic light chain 
amyloidosis;
d.   
Adult T-cell 
leukemia/lymphoma – as subsequent therapy;
e.   
Waldenstrom 
macroglobulinemia/lymphoplasmacytic lymphoma;
f.    
T-cell acute 
lymphoblastic leukemia (T-ALL) – for relapsed or refractory disease;
g.   
Pediatric acute 
lymphoblastic leukemia (ALL) – as subsequent therapy
h.   
Pediatric Hodgkin 
lymphoma (HL) – as subsequent therapy in combination with ifosafamide and 
vinorelbine;
2.   
Prescribed by or in 
consultation with an oncologist or hematologist;
3.   
Age > 18 years 
(all indications except pediatric ALL and HL);
4.   
Dose is within FDA 
maximum limit for any FDA-approved indication or is supported by practice 
guidelines or peer-reviewed literature for the relevant off-label use
 
Initial Approval 
Duration: 6 months
 
For Continued Therapy 
request, member must be responding positively to therapy and dose must be 
consistent with initial approval dosing requirements.
 
Continuation of therapy 
approval duration: 12 months
 
Codes 
Used In This BI:
 
1)   
J9041 – Injection, 
bortezomib (Velcade) 0.1mg