Initial Approval Criteria
A.
Multiple Myeloma and
Mantle Cell Lymphoma (must meet all):
1. Diagnosis of one of
the following (a or b):
a.
Multiple Myeloma
b.
Mantle Cell Lymphoma
(B-cell lymphoma subtype);
2.
Prescribed by or in consultation with an
oncologist or hematologist;
3. Age > 18 years;
4. Request meets the following:
a. Dose
does not exceed 1.3mg/m2;
5.
Dose is supported by practice guidelines or
peer-reviewed literature for the relevant off-label use (prescriber
must submit supporting evidence).
Initial Approval
Duration: 6 months.
B.
NCCN Recommended Uses
(off-label) (must meet all):
1.
Diagnosis of one of the
following (a-h):
a.
AIDS-related Kaposi
sarcoma (advanced cutaneous, oral, visceral, or nodal disease) – after 2 or more
prior lines of systemic therapy
b.
Multicentric Castleman’s
disease (B-cell lymphoma subtype) – as subsequent therapy
c.
Systemic light chain
amyloidosis;
d.
Adult T-cell
leukemia/lymphoma – as subsequent therapy;
e.
Waldenstrom
macroglobulinemia/lymphoplasmacytic lymphoma;
f.
T-cell acute
lymphoblastic leukemia (T-ALL) – for relapsed or refractory disease;
g.
Pediatric acute
lymphoblastic leukemia (ALL) – as subsequent therapy
h.
Pediatric Hodgkin
lymphoma (HL) – as subsequent therapy in combination with ifosafamide and
vinorelbine;
2.
Prescribed by or in
consultation with an oncologist or hematologist;
3.
Age > 18 years
(all indications except pediatric ALL and HL);
4.
Dose is within FDA
maximum limit for any FDA-approved indication or is supported by practice
guidelines or peer-reviewed literature for the relevant off-label use
Initial Approval
Duration: 6 months
For Continued Therapy
request, member must be responding positively to therapy and dose must be
consistent with initial approval dosing requirements.
Continuation of therapy
approval duration: 12 months
Codes
Used In This BI:
1)
J9041 – Injection,
bortezomib (Velcade) 0.1mg